n.甲糖宁(一种治糖尿病的药)

Results: Significant improvement of dissolution of tolbutamide was found. 结果:甲苯磺丁脲片的溶出度有很大程度提高。

Methods: L-HPC was added into tolbutamide and its dissolution was measured. 方法:于甲苯磺丁脲中加入低取代羟丙基纤维素测定溶出度。

Tolbutamide, indomethacin and diclofenac interacted with each other, resulting in the decreased formation of metabolites catalyzed by CYP2C9. 底物药物甲苯磺丁脲、双氯芬酸和吲哚美辛之间存在代谢相互作用，导致生成相应代谢物的产率降低。

OBJECTIVE To develop a method for separating and purifying the two main metabolites of tolbutamide, carboxytolbutamide (CTOL) and hydroxytolbutamide (OTOL), from human urine, then identify the production and determine its purity. 目的研究从生物体液(尿液)中分离纯化甲苯磺丁脲的两个主要代谢物羟基甲苯磺丁脲(OTOL)和羧基甲苯磺丁脲(CTOL)的方法,并对所得的产物进行鉴定和含量测定。

intravenous tolbutamide tolerance test 静脉甲磺丁脲耐量试验