普卢利沙星
HPLC method for determination of prulifloxacin was established. 建立了HPLC法测定普卢利沙星的含量。
Prulifloxacin, a new prodrug of ulifloxacin, is a broad-spectrum oral fluoroquinolone antibacterial agent. 普利沙星是新口服的氟喹诺酮类抗菌药。
After absorption, prulifloxacin is metabolised by esterases to ulifloxacin, which inhibits the formation of superhelix, cell division and reproduction by interfering the DNA toposomerase. 本品为前体药,其活性代谢产物通过阻碍DNA拓扑异构酶使细菌DNA无法形成超螺旋,导致细菌细胞无法分裂繁殖。
Keywords Prulifloxacin;nuclear magnetic resonance;signal assignment; 普卢利沙;核磁共振;信号归属;
Keywords Prulifloxacin;Levofloxacin;Acute bacterial infections;Double blind double dummy;Multicenter randomized controlled clinical study; 普卢利沙星;左氧氟沙星;急性细菌感染;双盲双模拟;多中心临床试验;
